Cellular Expression of INK4a Gene in Cells of Bladder Cancer Associated with Human Papilloma Virus-16

Hyperexpression of p16 INK4a protein is an early marker of cervical cancer. Hyperexpression of INK4a gene encoding this protein at the level of mRNA and p16 INK4a was detected in tumor cells of some patients with bladder cancer associated with human papilloma virus-16. However, in contrast to cervical cancer, this phenomenon in urothelial carcinomas does not correlate with expression of human papilloma virus-16 oncogenes E6 and E7.