Oxidative methods for synthesis ofα,α′-dioxygen-containing derivatives of dehydrodesthiobiotin

The action of selenium dioxide in dioxane on the ethyl ester ofα-ketodebydrodesthiobiotin and of lead tetraacetate in glacial acetic acid on its N,N′-diacetyl derivative give the corresponding ethyl esters ofα,α′-dioxodehydrodesthiobiotin andα-oxo-α′-acetoxy-N,N′-diacetyldehydrodesthiobiotin.