Expression of neuronal guidance factor Slit2 in the spinal cord of chick embryonic development

Objective To explore the expression of neuronal guidance factor Slit2 in the neural tube and spinal cord of chick embryonic development. Method The protein expression pattern of Slit2 was detected in the neural tube(HH6-HH10) and spinal cord(3d-17d) using immunohistochemistry. Results Slit 2 positive product was detected in different stages of neural tube and spinal cord of chick embryo, superior in the spinal cord midline of neural floor plate to other regions, especially on 9 day chick embryo, but showed an attenuated and diffused trend after 11 days. Conclusion The expression pattern of neuronal guidance factor Slit2 in the neural tube and spinal cord of chick embryo presented a dynamic change.