Mechanism-guided repurposing: Effect of deferiprone on the eIF5A hydroxylation-dependent synthesis of proline cluster-containing proteins (PccPs) in uterine serous carcinoma (USC).

e23159Background: Hydroxylation of eIF5A by deoxyhypusyl hydroxylase (DOHH) forms its hypusine residue, which relieves stalling within the ribosomal exit tunnel of a subset of nascent, cellular or ...