One method of synthesis of acetyl-carnosine n-

The present invention relates to a method for the synthesis of N- acetyl-carnosine, the method β- alanine methyl ester as a starting material, the amino group of the 2,4,6-trimethoxybenzyl modification, thereby improving propan β- acid starting material in an organic solvent solubility, decreased solubility in water, after further amino acetylation, hydrolyzed with methyl, then condensed with histidine methyl ester, methyl ester after hydrolysis off, deprotection by acid, Finally, strong acid cation resin absorbed aqueous ammonia to give N- acetyl-carnosine. Compared with the prior art, the process of the present invention can effectively solve the difficult separation of intermediates, avoiding the use of expensive problems carnosine as raw material, there is provided another method of synthesis for the synthesis of N- acetyl-carnosine.