La paniculitis lúpica como primera manifestación de lupus eritematoso sistémico en paciente con drepanocitosis

El lupus eritematoso sistemico (LES) y la anemia drepanocitica (AD) comparten caracteristicas clinicas similares, como poliartralgia, anemia, fiebre, dolor visceral y compromiso renal, cardiovascular y pulmonar. Debido a la superposicion clinica, el diagnostico de LES en pacientes con AD puede ser dificil. En la literatura se han reportado 40 casos con esta asociacion en los ultimos 50 anos. Algunos autores han sugerido una posible relacion etiopatogenica entre ambas entidades. Se reporta el caso de una paciente con diagnostico de anemia drepanocitica que presento paniculitis lupica como primera manifestacion de lupus eritematoso sistemico. Es importante que los pacientes con anemia drepanocitica que presenten manifestaciones cutaneas inusuales sean evaluados por un dermatologo. Lupus panniculitis as the first manifestation of systemic lupus erythematosus in a patient with sickle cell disease. Abstract: Systemic lupus erythematosus (SLE) and sickle cell anemia (SCA) share similar clinical features, such as polyarthralgia, anemia, fever, visceral pain and renal, cardiovascular and pulmonary impairments. Due to the clinical overlap, the diagnosis of SLE in patients with SCA can be difficult. In the literature, 40 cases with this association have been identified over the last 50 years. Some authors have suggested a possible etiopathogenic relationship between the two entities. Herewith, we present a patient diagnosed with sickle cell anemia and a lupus panniculitis as the first manifestation of systemic lupus erythematosus. It is important that patients with sickle cell anemia showing unusual skin manifestations are evaluated by a dermatologist.