The kinetics of skin thinning induced by topical fluticasone propionate 0·05% cream in volunteer subjects

Summary Fluticasone propionate (FP) 0·05% (CutivateTM) cream is a novel corticosteroid used for the treatment of corticosteroid-responsive dermatoses. To date there are no published data concerning its effect on cutaneous atrophy. This randomized, double-blind study of 40 volunteer subjects was performed to investigate the kinetics of skin thinning induced by topical 0·05% FP cream vs. placebo after once-daily application for 2–8 weeks. The results of this study showed no significant effect on the skin thickness of subjects after 8 weeks' treatment with 0·05% FP cream compared with placebo.