Theoretical and neurophysiological analysis of the functions of the primate hippocampus in memory.

The aims of this paper are to consider which spatial functions are performed by the primate hippocampus, how these are related to the memory functions performed by the hippocampus, and how the hippocampus performs these functions. In addition to the evidence that is available from anatomical connections, the effects of lesions to the system, and recordings of the activity of single neurons in the system, neuronal network models of hippocampal function will also be introduced, as they have the promise of enabling one to understand what and how the hippocampus computes, and thus the functions being performed by the hippocampus. Many of the studies described have been performed with macaque monkeys to provide information as relevant as possible to understanding amnesia in humans. Effects on memory are produced by damage to the hippocampus or to some of its connections, such as the fornix, and these structures are collectively referred to below as the hippocampal system.