Clinical analysis of the correlation between urinary iodine level and thyroid funtion in urban residents of Hefei

Objective To investigate the relationship between urinary iodine level and prevalence of thyroid disease by comparing the levels of urinary iodine in patients with thyroid disease and healthy people in Hefei urban residents. Methods A prospective study was used in the study. A total of 238 patients with thyroid disease were enrolled in the Third Affiliated Hospital of Anhui Medical University from March 2015 to January 2017, and these patients were divided into three groups: Graves's disease (GD) group (n= 116), chronic lymphocyticthyroiditis (HT) group (n= 79) and thyroid nodule group (n= 43), 568 cases of Hefei urban residents without thyroid disease were selected as control group Urinary iodine was measured by arsenic-cerium catalyzed spectrophotometry. Thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) were measured by chemiluminescence immunoassay. The thyroid was examined through B ultrasonography in both the case group and the control group. Results The median urinary iodine concentrations(MUIC) of GD group, HT group, thyroid nodule group and control group were 326.83, 361.49, 235.26, and 195.63 μg/L, there were significant differences in the MUIC between the 4 groups (H= 20.13, P 0.05). Conclusions According to the urinary iodine level in the normal population, the Hefei urban area belongs to the area of appropriate iodine. There was no corrolation between urinary iodine level and thyroid function in urban residents of Hefei. Key words: Urine; Iodine; Thyroid disease