3LC-3 : Synthetic Biology for Industrial Biotechnology

Pathway optimization of microbial metabolism is essential for the production of commercially valuable chemicals such as biofuels, platform chemicals and biologically active compounds. To achieve the successful design or redesign of microbial metabolism, a variety of synthetic biology tools should be required. In this study, we developed the general tools such as UTR Designer and Riboselector to modify the microbial physiology for the production of value-added chemicals at the various levels including translation and protein levels. In addition, we recently isolated a novel microorganism that can utilize macroalgae with fast metabolic activity. To engineer this organism, synthetic biology tools were developed based on the information obtained from systems biology approach. Conclusively, the potentials of the platform technology developed in this study for the application to the production of biofuels and a variety of value-added chemicals.