Immunhistochemische Untersuchungen zur Neuroanatomie der menschlichen Nasenmuschel: Innervationsmuster der seromukösen Drüsen

: Seromucous glands are among the main components of human nasal mucosa. To control the different physiological functions of these glands, a dense nerval network is necessary. The aim of this study was to demonstrate the general innervation of the seromucous glands in nasal mucosa. Tissue samples of inferior human turbinates were fixed and embedded in paraffin wax or frozen. Serial sections were performed and incubated with antibodies either to neuron-specific enolase (NSE) or S-100 protein. The ABC method was employed to demonstrate the immunacomplexes. The sections were counterstained with haemotoxylin. Either NSE and S-100 protein-immunoreactive nerve fibres were found around the acini, ducts and in the connective tissue of the glands. Furthermore, a dense network of fine nerve fibres was detected in the submucosal region. The localisation of neurons in nasal glands confirms the direct nerval control of the diverse glandular functions. Additionally, the sensitive subepithelial network of fine nerve fibres might be involved in the regulation of glandular secretion.