Facilely tuning the bioactivity of an orthopedic implant surface based on nanostructured polypyrrole/glycosaminoglycans

Herein, we report a facile approach to tune the bioactivity of orthopedic implants. The wettability of a Ti-6Al-4V orthopedic implant surface based on nanostructured polypyrrole (NPPy) doped with glycosaminoglycans (GAGs, major extracellular matrix components) can be controlled by in situ electrical stimulus, which was utilized to tune their bioactivity.