Thermoresponsive cyclic peptide--poly(2-ethyl-2-oxazoline) conjugate nanotubes.

We describe the synthesis of self-assembling cyclic octapeptides of alternating D- and L-chirality conjugated to two poly(2-ethyl-2-oxazoline) chains. The resulting conjugates form nanotubes in water, which are reversibly transformed into microparticles as the temperature reaches the cloud point temperature of the conjugate.