Deoxyribonuclease partially ameliorates thioacetamide-induced hepatorenal injury

Lenka Vokalova,Lucia Lauková,Jozef Čonka,Veronika Melišková,Veronika Borbélyová,Janka Bábíčková,L’ubomíra Tóthová,Július Hodosy,Barbora Vlková,Peter Celec

Deoxyribonuclease partially ameliorates thioacetamide-induced hepatorenal injury

2017

Lenka Vokalova
Lucia Lauková
Jozef Čonka
Veronika Melišková
Veronika Borbélyová
Janka Bábíčková
L’ubomíra Tóthová
Július Hodosy
Barbora Vlková
Peter Celec

Thioacetamide-induced hepatorenal injury resulted in higher plasma cell-free DNA. Deoxyribonuclease decreased average cell-free DNA of mitochondrial origin but not nuclear origin. Deoxyribonuclease partially prevented hepatorenal injury in rats.

Keywords:

Biochemistry
Diabetes mellitus
Thioacetamide
Deoxyribonuclease
Biology
Hepatorenal syndrome
DNA
treatment outcome
Deoxyribonucleases
liver failure

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