Medicinal dasatinib composition and preparation method thereof

2012 
The invention relates to a medicinal dasatinib composition and preparation method thereof. The composition comprises an effective amount of dasatinib and medicinal auxiliary materials, wherein dasatinib is an anhydride, and the medicinal materials comprise 3-15 percent by weight of retardant; the retardant is a hydrophilic gel material, and is selected from hydroxypropylmethyl cellose, methyl cellulose, carbopol or alginate. The invention also provides a preparation method of the medicinal dasatinib composition. According to the medicinal dasatinib composition, the microenvironment of the solid preparation can be improved due to the retardant, so that the preparation stability can be improved on one hand, and on the other hand, the dissolution velocity of the oral preparation can be controlled. The medicinal dasatinib composition is simple in process and low in cost, and does not have pollution.
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