Derivatives of (phenylsulfonamido-methyl)nicotine and (phenylsulfonamido-methyl)thiazole as novel 11β-hydroxysteroid dehydrogenase type 1 inhibitors: synthesis and biological activities in vitro

Xu Zhang,Yang Zhou,Yu Shen,Lili Du,Junhua Chen,Ying Leng,Jianhua Shen

Derivatives of (phenylsulfonamido-methyl)nicotine and (phenylsulfonamido-methyl)thiazole as novel 11β-hydroxysteroid dehydrogenase type 1 inhibitors: synthesis and biological activities in vitro

2009

Xu Zhang
Yang Zhou
Yu Shen
Lili Du
Junhua Chen
Ying Leng
Jianhua Shen

Derivatives of (phenylsulfonamido-methyl)nicotine and (phenylsulfonamido-methyl)thiazole as novel 11β-hydroxysteroid dehydrogenase type 1 inhibitors: synthesis and biological activities in vitro

Keywords:

Dehydrogenase
Nicotine
Microsome
11β-hydroxysteroid dehydrogenase type 1
Thiazole
Binding site
Stereochemistry
Structure–activity relationship
Chemistry
In vitro
Biochemistry
Enzyme
Molecular model
Scintillation proximity assay
Docking (molecular)

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