Allometric pharmacokinetic scaling: towards the prediction of human oral pharmacokinetics.

Meihua Rose Feng,Xiaochun Lou,Richard R. Brown,Athiwat. Hutchaleelaha

Allometric pharmacokinetic scaling: towards the prediction of human oral pharmacokinetics.

2000

Meihua Rose Feng
Xiaochun Lou
Richard R. Brown
Athiwat. Hutchaleelaha

Purpose. To evaluate (1) allometric scaling of systemic clearance (CL)using unbound drug concentration, (2) the potential usage of brainweight (BRW) correction in allometric scaling of both CL and oralclearance (CL/F).

Keywords:

Volume of distribution
Allometry
Pharmacology
Scaling
Bioavailability
Body weight
Chemistry
Chromatography
Pharmacokinetics
unbound drug
pharmacology toxicology

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