One-pot synthesis of phosphate diesters and phosphonate monoesters via a combination of microwave-CCl3CN–pyridine coupling conditions

Abstract Simple and convenient one-pot synthesis of a phosphorus–oxygen bond in phosphate diesters and phosphonate monoesters using trichloroacetonitrile as an activating agent and pyridine as a solvent under microwave irradiation conditions was described. This method is useful for the preparation of various biologically interesting glycophospholipids and also phosphate diesters or phosphonate monoesters containing diverse moieties such as alkyl, prenyl, and benzyl substituents.