Musidunin and musiduol, insect antifeedants from Croton jatrophoides

Two novel limonoids, musidunin (1) and musiduol (2), were isolated from a methanol extract of Croton jatrophoides by bioassay-guided fractionation. Their structures were established by extensive NMR experiments. Interestingly, A,B-seco limonoid 1 contains a unique acetal annulation of A, A‘, and B‘ rings. Both limonoids exhibited antifeedant activities against two pests, Pectinophora gossypiella and Spodoptera frugiperda.