Potent new cell adhesion inhibitory compounds from the root of Trichilia rubra

Abstract A series of seco-limonoids, with uncommon hemi ortho ester A-rings, was isolated from the root of Trichilia rubra . Their structures were determined by extensive spectroscopic studies. The five new and two previously known compounds were all found to be potent inhibitors of LFA-1:ICAM-1 mediated cell adhesion.