Inhibition by RNAi expression of alpha-ENaC

Composition comprising an RNAi agent comprising a sense strand and an antisense strand, laque: a. the sense strand comprises at least 19 contiguous nucleotides of the sense strand of ND8356 (SEQ ID NO: 143) and the antisense strand comprises at least 19 contiguous nucleotides of the antisense strand of ND8356 (SEQ IDNO: 144); or b. the sense strand comprises at least 19 contiguous nucleotides of the sense strand of ND8379 (SEQ ID NO: 189) and the antisense strand comprises at least 19 contiguous nucleotides of the antisense strand of ND8379 (SEQ IDNO: 190); or c. the sense strand comprises at least 19 contiguous nucleotides of the sense strand of ND8572 (SEQ ID NO: 447) and the antisense strand comprises at least 19 contiguous nucleotides of the antisense strand of ND8572 (SEQ IDNO: 448); or d. the sense strand comprises at least 19 contiguous nucleotides of the sense strand of ND8595 (SEQ ID NO: 493) and the antisense strand comprises at least 19 contiguous nucleotides of the antisense strand of ND 8595 (SEQ IDNO: 494).