Proliposomes as Pharmaceutical Drug Delivery System: A Brief Review

Liposomes, the microscopic vesicles, are composed of a bilayer of phospholipids and a novel drug delivery system that provides drug at predetermined rate decided according to need, pharmacological aspects, drug profile, physiological conditions of body etc. But liposomes exhibit poor stability problem and this leads to their storage problem. To circumvent this problem Pro-liposomes (PLs) were discovered in 1986. Pro-liposomes are free flowing granular products composed of drug and phospholipid precursors which on hydration lead to liposomes. This paper reviews various features regarding pro-liposomes, their method of preparation, evaluation, applications and pointing out its potential to be employed for different routes of administration.