Degradation of intracellular TGF-β1 by PROTACs efficiently reverses M2 macrophage induced malignant pathological events

The first proteolysis targeting chimeras for intracellular elimination of transforming growth factor-β1 (TGF-β1), which contributes to various diseases, is described. The appropriate designed DT-6 could efficiently degrade intracellular TGF-β1, and inhibit M2 macrophage induced epithelial to mesenchymal transition and invasive migration of cancer cells.