Simultaneous inheritance andexpression ofclassical haemophilia A andtypeIIAvon Willebrand' sdisease

VonWillebrand's disease isaheterogeneous group ofautosomally transmitted bleeding disorders, whicharecharacterised clinically bybruising and mucousmembrane bleeding andbythelaboratory findings ofquantitative orqualitative abnormalities of factor VIIIactivities (FVIIIprocoagulant, VIII: C;related antigen, VIIIR: AG;vonWillebrand factor, VIIIR: WF).' 2Recently, anumberofvariant (typeII)formsofvonWillebrand's disease have beencharacterised bymultimeric analysis ofthevon Willebrand protein (VIIIR:AG/VIIIR: WF)