Development and Scale-Up of an Improved Manufacturing Route to the ATR Inhibitor Ceralasertib

Mark A. Graham,Hannah Askey,Andrew D. Campbell,Chan Lai,Katie G. Cooper,Zhaoshan Cui,Andrew Dalgleish,David Dave,Gareth AstraZeneca R D Charnwood Ensor,Maria Rita Galan Espinosa,Peter Hamilton,Claire Heffernan,Lucinda V. Jackson,Dajiang Jing,Martin F. Jones,Pengpeng Liu,Keith R. Mulholland,Mohammed Pervez,Michael Popadynec,Emma Randles,Simone Tomasi,Shenghua Wang

Development and Scale-Up of an Improved Manufacturing Route to the ATR Inhibitor Ceralasertib

2020

Ceralasertib is currently being evaluated in multiple phase I/II clinical trials for the treatment of cancer. Its structure, comprising a pyrimidine core decorated with a chiral morpholine, a cyclo...

Keywords:

Combinatorial chemistry
Nucleophilic aromatic substitution
Chirality (chemistry)
Pyrimidine
Morpholine
Cyclopropanation
Chemistry

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