Palladium-catalyzed β-selective C(sp2)–H carboxamidation of enamides by isocyanide insertion: synthesis of N-acyl enamine amides
2017
An efficient synthesis of N-acyl enamine amides via palladium-catalyzed alkene C–H activation and isocyanide insertion has been developed. The reaction was realized with good regioselectivity through directing-group-assisted alkenyl C(sp2)–H bond carboxamidation under mild conditions. A facile pathway to β-amino amides was achieved via reduction of the synthesized N-acyl enamine amides.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
114
References
19
Citations
NaN
KQI