Effects of the dose on the prognosis of dynamics of blood neutrophil count based on cytogenetic analysis of lymphocytes of victims of the Chernobyl AES accident

: The authors investigated prognostic significance of irradiation intensity with relation to the severity of a course of the bone marrow syndrome in the affected population at the Chernobyl accident. Absorbed doses were determined by analysis of lymphocyte chromosome aberrations and the time course of the blood neutrophil count. The evaluation of the severity of blood disorders by cytogenetic and hematological tests was shown to coincide in 85% of patients. Due to lack of information on irradiation physical data, an absorbed dose mean rate was assessed for the entire period of stay in the high radiation zone. In 81 patients mean dose rate values varied within 0.1-22 Gy/h. Further analysis has shown that a mean dose rate value in this range did not influence the prognosis of a course of the bone marrow syndrome in the affected persons (by the results of cytogenetic investigation of lymphocyte cultures).