Conformational analysis of cis-fused eudesm-11-en-4-ols

The conformational behaviour of the four cis-fused stereoisomers 1–4 of eudesm-11-en-4-ol has been investigated using NMR spectroscopy. In addition, the conformational behaviour of these compounds has been simulated with molecular-mechanics calculations using the MM2(87) force-field program. Comparison of the results obtained from NMR analysis and MM2 calculations shows that the outcome of both methods agree very well.