ORIGINAL ARTICLE TRICLOSAN INDUCED GENOTOXIC EFFECT ON ZEBRA FISH, Brachydanio rerio BY USING ALKALINE COMET ASSAY.

Triclosan (TCS) is commonly used as an antibacterial and antifun gal agent in household cleaning products. TCS can be bio accumulated and create endocrine-disrupting and damaging the DNA in some exposed fish. The present work has been proposed to study the effects of sub-lethal concentrations of triclosan on the blood of DNA damage by using comet assay on blood erythrocyte of zebra fish, Brachydanio rerio after 7 and 28 days exposure. The present study results shows, the highest erythrocyte tail DNA damage was observed in 28 days of exposure and following low level of tail DNA observed at 7 days of exposure. These genotoxic acessment along with the oxidative stress could be effectively used as potentia l non-specific biomarkers of peticides toxicity to the freshwater fish in the field of environmental biomonitoring.