S100 beta is a marker of brain insult caused by systemic inflammatory response syndrome

Central nervous system (CNS) failure along with other systems is included in septic multiorgan failure; however, in our opinion, it is the less studied. Earlier, a S100β level rise was described for septic encephalopathy patients, but together with this sites of a local ischemia or a bleed were discovered according to computer tomography in a brain [1]. The purpose of the present study is to determine whether it is the functional or the organic CNS insult that defines septic encephalopathy and to study the dependence of septic encephalopathy on the severity of sepsis.