Preparation of [66Ga]bleomycin complex as a possible PET radiopharmaceutical

Gallium-66 (T1/2 = 9.49 h) is an interesting radionuclide that has potential use for positron emission tomography (PET) imaging of biological processes in intermediate to slow target tissue uptake. 66Ga was produced in the NRCAM cyclotron as a result of 15 MeV proton bombardment of 66Zn with current intensity of 180 μA (yield 11.2 mCi/μAh). Bleomycin (BLM) was labeled with [66Ga]GaCl3