Synthesis, characterization, in silico and antifungal studies of thiazolidine analogues

Abstract A series of sixteen novel heterocyclic thiazolidine derivatives ( 3a-p ) was synthesized upon reaction of L-cysteine with different substituted benzaldehyde. The synthesized compounds were extensively characterized by IR, 1 H and 13 C NMR spectral analysis. All compounds were evaluated for their anti-fungal activity against Candida albicans and Aspergillus niger using fluconazole as reference drug. The assay revealed that, compound 3k showed significant activity (14 mm ZOI, 64 µg/mL IC 50 and 15 mm ZOI, >32 µg/mL IC 50 ) against C. albicans and A. niger , respectively.