Distribution and drug resistant changing of pathogens in blood culture specimens: a survey of six years in a general hospital.

OBJECTIVE To explore and compare the distribution and drug resistance changing of pathogens in two stages(2003-2005 and 2005-2008) blood culture specimens.METHODS The blood culture results in two stages was analyzed retrospectively by WHONET 5.3 software.RESULTS The main pathogenic bacteria isolated from the two stages were Gram-negative bacteria.The most obvious changes in pathogens distribution were the isolating rate increasing in non-fermentative Gram-negative bacilli(from 5.1% to 22.4%),but the isolating rate reduced in Salmonella(from 26.9% to 4.3%).In addition,The isolating rate of Enterococcus(from 2.1% to 6.9%)and fungi(from 4.5% to 8.2%)were also changed.Meanwhile,the ascending tendency of drug resistance rate in these pathogenic bacteria was shown.CONCLUSIONS The pathogens distributions in two stages have remarkable change and the drug resistance has striking growth.As a result,it is important for patients with suspected septicemia to strengthen pathogen detection.