Effect of β-sodium aescinate on content of TNF-α in serum of experimental rats with cerebral hemorrhage.

Objective To investigate the effect of β-sodium aescinate on TNF-αand brain edema in rats with cerebral hemorrhage.Methods Seventy-eight adults SD rats were randomly divided into sham operration group、hemorrhage group、 intervention group treated with β-sodium aescinate and control group.Animal model was established by injecting collegenase Ⅶ into left candoputamen of adult rat under stereotaxic apparatus.The cerebral water content was measured by dry-wet weight method.To mesure the TNF-α content in serum with ELASA.The ultrastructure histopathologic changes of perilesion zons of cerebral hemorrhage were observed under electronic microscope.Results The cerebral water content in the intervention group were significently different from those in the control group.(P0.01)The TNF-α content of therapeutic group treated with β-sodium aescinate decrease significantly at 24h and 3day after hemorrhage.However,There is no difference between there groups at 7 day after hemorrhage.The histopathologic results showed that the edema of neuron and endothelial cell were more severe in control group than that of intervention group.Conclusion β-sodium aescinate is effective for treatment of cerebral hemorrhage and cerebral edema.