DEVELOPMENT AND EVALUATION OF SUBLINGUAL TABLETS OF ARIPIPRAZOLE
2014
Aripiprazole is an antipsychotic drug used for the treatment of schizophrenia. The present study aimed to develop the sublingual tablets were prepared by direct compression method by using various ingredients such as Crospovidone, Crosscarmellose sodium, Sodium starch glycolate, Microcrystalline cellulose, Aspartame, Aerosil and Magnesium stearate. Fourier transform infrared spectroscopy was confirmed the absence of any drug- polymer interactions. Twelve formulations (F1-F12) of sublingual tablets were prepared by using the various concentrations of super disintegrate. The formulated tablets were evaluated for thickness, hardness, weight variation, friability, wetting time, water absorption ratio, disintegration time, drug content and in-vitro drug release studies. The optimized formulation F12 was found, which provided short wetting time of 25 sec, water absorption ratio of 65 and disintegration time of 27 sec. The best in- vitro drug release was found to be 97.17% at the end of 14 min for the formulation F12.
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