Expedient synthesis of 5-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones

Thomas G. Steele,Craig A. Coburn,Michael A. Patane,Mark G. Bock

Expedient synthesis of 5-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones

1998

Thomas G. Steele
Craig A. Coburn
Michael A. Patane
Mark G. Bock

Abstract A new procedure for the synthesis of 5-unsubstituted 3,4-dihydropyrimidin-2(1 H )-ones is described. Two plausible mechanisms for the key chemical transformation are advanced.

Keywords:

Pyrimidinones
Chemical transformation
Biginelli reaction
Decarboxylation
Chemistry
Organic chemistry

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