Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases

Jacynthe L. Toulouse,Genbin Shi,Claudèle Lemay-St-Denis,Maximilian C. C. J. C. Ebert,Daniel H. Deon,Marc Gagnon,Edward H. Ruediger,Kévin Saint-Jacques,Delphine Forge,Jean Jacques Vanden Eynde,Anne Marinier,Xinhua Ji,Joelle N. Pelletier

Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases

2020

Jacynthe L. Toulouse
Genbin Shi
Claudèle Lemay-St-Denis
Maximilian C. C. J. C. Ebert
Daniel H. Deon
Marc Gagnon
Edward H. Ruediger
Kévin Saint-Jacques
Delphine Forge
Jean Jacques Vanden Eynde
Anne Marinier
Xinhua Ji
Joelle N. Pelletier

Trimethoprim (TMP) is widely used to treat infections in humans and in livestock, accelerating the incidence of TMP resistance. The emergent and largely untracked type II dihydrofolate reductases (...

Keywords:

Trimethoprim
Type II dihydrofolate reductase
Chemistry
Microbiology
dual target
Trimethoprim Resistance

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