Contrasting effect of interleukin-4 on the expression of cytosolic phospholipase A2, 5-lipoxygenase and 5-lipoxygenase-activating protein in peritoneal macrophages from control and ovalbumin-sensitized rats.

INTRODUCTION Interleukin-4 (IL-4) is a Th2-derived cytokine involved in the modulation of inflammatory processes. It is considered as an anti-inflammatory cytokine because it inhibits the production of inflammatory cytokines such as IL-1beta and TNF-alpha in monocytes/macrophages [1-3], the expression of receptors such as CD14 and TNF receptors [4, 5], and it amplifies the expression of anti-inflammatory products such as the IL-1 receptor [...]