A multicenter and case-control study of human papillomavirus and laryngeal cancer in a Chinese population

But de la presentation Substantial molecular evidence suggests a role for human papillomavirus (HPV) in the pathogenesis of laryngeal squamous cell carcinoma (LSCC), but epidemiologic and prognosis data have been inconsistent in a Chinese population. Materiel et methodes This multicenter and case control study included 674 LSCC patients and 674 control patients treated in three centers in Shanghai from 2006 till 2013. We used immunohistochemistry (IHC) and GenoArray genotyping assay to evaluate the HPV infection status and determined its prevalence and influence on disease prognosis. Resultats The total prevalence of HPV DNA was 4,9 % (33/674) in LSCC patients and 0 % (0/674) in control cases in our series ( P P P P P  = 0.30). The 3-year disease progression-free rate was 65.1 % for HPV positive patients and 58.3 % for HPV negative ones ( P  = 0.37). Conclusion A very low prevalence of HPV was among LSCC patients in a Chinese population. HPV was more common in nonsmokers, non-drinkers and supraglottic LSCC patients. The presence of HPV DNA was not associated with patients’ overall survival and disease progression-free rate in our series.