Fluoride Induced Histopathological Changes in Liver of Albino Rabbit - An Experimental Study

Fluoride causes serious health problems, as it is a well determined non-biodegradable and moderate pollutant. The present study was designed to investigate the histopathalogical changes in liver of albino rabbits after exposing them to sodium fluoride. 24 adult albino rabbits were divided into 3 groups (8 rabbits per each group). The first group served as controls and received de-ionized water. The second group was treated with 0.5% of sodium fluoride solution and third group was treated with 3% of sodium fluoride solution for 16 weeks. At 2 weeks interval of the treatment period, 1 animal from each group were sacrificed by cervical dislocation and liver was dissected out. The liver tissue was cleared and processed to assess the histopathalogical changes. The histopathological results in the present study indicate that exposure to sodium fluoride from 15 days to 16 weeks in high doses caused necrotic changes in hepatocytes and liver sinusoids.