Синтез и противовирусная активность замещенных этил-2-аминометил-5-гидрокси-1 H -индол-3-карбоновых кислот и их производных

New substituted 2-aminomethyl-5-hydroxy-1 H -indole-3-carboxylic acids and their derivatives have been synthesized and their antiviral activity against BVDV, HCV, and A/Aichi/2/69(H3N2) influenza viruses has been studied in vitro . Among all synthesized compounds, only two – ethyl 5-hyroxy-2-(dimethylaminomethyl)-1-methyl-6-piridine-3-yl-1 H -indole-3-carboxylate and ethyl 5-hyroxy-2-(dimethylaminomethyl)-1-methyl-6-fluoro-1 H -indole-3-carboxylate-exhibited significant activity against the indicated viruses. These compounds in micromolar amounts effectively suppressed the replication of A/Aichi/2/69(H3N2) virus in a cell culture. The efficacy of these drugs in a dose of 25 mg/kg exceeded that of the reference drug arbidol on the model of influenza-induced pneumonia in mice infected with influenza A/Aichi/2/69 (H3N2) virus.