Neurochemical mechanisms of the action of euphylline in cerebrovascular insufficiency

In cerebrovascular insufficiency the ammonia concentration in the brain tissue shows a marked increase, glutamate dehydrogenase (GD) activity was reduced, and there is no significant change in the levels of glutamine and protein amino groups. Euphylline, which promotes normalization of the disturbed cerebral circulation, removes the excess of ammonia by restoring GD activity in the reductive amination reaction. The effect of euphylline is most clearly demonstrated in the presence of acute cerebral ischemia, evidence of the effect of the drug on the neurochemical mechanisms of compensatory regulation of the cerebral blood flow.