Inflammation, Adipokines, and Gestational Diabetes Mellitus

Chronic subclinical inflammation and dysregulation of adipocyte-derived proteins (adipokines) have emerged as novel, non-traditional risk factors for both type 2 diabetes and cardiovascular disease. Since GDM is associated with future risk of both of these conditions, study of these novel risk factors in women with GDM has grown. Indeed, these factors may potentially contribute to (i) the development of GDM in affected women, and (ii) their future risk of type 2 diabetes and vascular disease. This chapter reviews current evidence linking inflammation and adipokine dysregulation to GDM, both during and after pregnancy.