Drugs for preventing malaria in travellers (Review)

Summary of findings for the main comparison Atovaquone-proguanilcomparedtoMefloquineforNonimmunechild and adult travellers; Summary of findings 2 Doxycyclinecompared to Mefloquine for Non Immune Child and AdultTravellers; Summaryoffindings 3 Anystandarddrugscomparedto Chloroquine-proguanil for Non Immune Child and AdultTravellers Atovaquone-proguanil versus doxycycline One trial made this comparison (Schlagenhauf 2003a). Clinical outcomes No clinical outcomes were evaluated. Adverse outcomes For this comparison, only adverse events are available. Adverseevents were very commonly reported in both arms, but no dif-ference in effect was shown for any adverse events (317 partici-pants, Analysis 1.1), dermatological adverse events (317 partici-pants, Analysis 1.2), gastrointestinal adverse events (317 partici-pants,Analysis1.3),andneuropsychiatricadverseevents(317par-ticipants, Analysis 1.4).For serious adverse events , no event was reported. Secondary outcomes No difference was detected between the drugs in the number ofdiscontinuations of the study drug for any reason (317 partici-pants, Analysis 1.5).