Surgical results for prosthetic versus native valve endocarditis – a multicenter analysis

Structured Abstract Objectives Prosthetic valve endocarditis (PVE) is associated with worse outcomes compared to native valve endocarditis (NVE). Our aim was to evaluate the impact of NVE versus PVE on postoperative outcomes and long-term survival and to identify preoperative risk factors in a large cohort of 4300 infective endocarditis (IE) patients. Methods This retrospective cohort study was conducted in 5 German Cardiac Surgery Centers („CAMPAIGN“ (Clinical Multicenter Project of Analysis of Infective Endocarditis in Germany). Data of 4300 patients undergoing valve surgery for NVE and PVE were retrospectively analyzed. Uni- and multivariable analyses were used for risk stratification, Kaplan Meier analysis for long-term survival. In addition, we performed Cox proportional hazards regression with multivariable adjustment. Results Between 1994 and 2016, 3143 patients (73.1%) underwent surgery for NVE and 1157 (26.9%) for PVE. PVE patients were older (69 [60-75] vs. 63 [52-72] years; p Conclusions After adjusting for preoperative comorbidities, long-term survival for PVE and NVE is comparable. Hence, our large cohort study provides evidence, that PVE alone should not be a contraindication for redo operations.