Total Synthesis and Structural Assignment of Curvicollide C

The first total synthesis of (+)-curvicollide C has been accomplished. Cross-metathesis and Julia–Kocienski olefination were instrumental in the synthesis of 1,3-diene segments and allowed for a ternary-convergent synthetic design. A full structural assignment is proposed for (−)-curvicollide C, a uniquely structured polyketide of fungal origin.