Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

Lin Yuan,Yanrong Lv,Hongchang Li,Haidong Gao,Shanshan Song,Yuan Zhang,Guichun Xing,Xiangzhen Kong,Lijing Wang,Yang Li,Tao Zhou,Daming Gao,Zhi-Xiong Xiao,Yuxin Yin,Wenyi Wei,Fuchu He,Lingqiang Zhang

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

2015

Lin Yuan
Yanrong Lv
Hongchang Li
Haidong Gao
Shanshan Song
Yuan Zhang
Guichun Xing
Xiangzhen Kong
Lijing Wang
Yang Li
Tao Zhou
Daming Gao
Zhi-Xiong Xiao
Yuxin Yin
Wenyi Wei
Fuchu He
Lingqiang Zhang

By screening 85 deubiquitylation enzymes, Zhang and colleagues identify OTUD3 as an enzyme that upregulates PTEN levels by deubiquitylation and acts as a tumour suppressor in synergy with another PTEN DUB, USP13.

Keywords:

PTEN
Cell biology
Ubiquitin
Suppressor
Molecular biology
Ubiquitin-Specific Proteases
Signal transduction
Mutation
Cancer research
Carcinogenesis
Proto-Oncogene Proteins c-akt
Biology
Transgene

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