Red de Unidades de Radiofarmacia de General Electric Healthcare. General Electric Healthcare

Aim: To determine the stability and radio chemical purity (RCP) of 99m Tc-tetrofosmin kept for different time intervals of up to 12 hours, the maximum recommended by the manufacturers, at different temperatures (18-25o C or room temperature, 32oC & 2-8oC), in both reactive equipment vials or in syringes, and to determine whether shorter or longer incubation times, other than the recommended 20 minute period, could affect the RCP of doses of the radiopharmaceutical. Materials and Methods: 40 vials of phosphine were labelled in accordance with manufacturer’s recommendations. Three different storage temperature conditions were studied, in order to determine how possible extremes may affect dosages of the drug. Results: The average RCP percentages of the radiofarmaceutical incubated in vials and syringes were 95.79±2.32 & 96.16±2.32 respectively, with no signifi cant differences observed. Stability at different temperatures and different time intervals was over 90% in all cases. Conclusions: The 99m Tc-tetrofosmin complex remains stable for 12 hours, whether it is incubated in the original reactive equipment or within insulin syringes with needle. Additionally, the radiopharmaceutical also remained stable at the different studied storage temperatures and at all time intervals for up to 12 hours.