BET bromodomain inhibitor HMBA synergizes with MEK inhibition in treatment of malignant glioma.

Elisa Funck-Brentano,Dzeneta Vizlin-Hodzic,Jonas Nilsson,Lisa M. Nilsson

BET bromodomain inhibitor HMBA synergizes with MEK inhibition in treatment of malignant glioma.

2020

Elisa Funck-Brentano
Dzeneta Vizlin-Hodzic
Jonas Nilsson
Lisa M. Nilsson

(1) Background: BET bromodomain proteins regulate transcription by binding acetylated histones and attracting key factors for, e.g., transcriptional elongation. BET inhibitors have been developed t...

Keywords:

Bromodomain
Biology
Histone
Cell biology
Transcription (biology)
Acetylation
key factors
transcriptional elongation
Molecular biology
Glioma
Hexamethylene bisacetamide

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