Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells

Angelo Castello,Mauro Gaya,Johannes Tucholski,Thomas Oellerich,Kun-Hui Lu,Anna Tafuri,Tony Pawson,Jürgen Wienands,Michael Engelke,Facundo D. Batista

Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells

2013

Angelo Castello
Mauro Gaya
Johannes Tucholski
Thomas Oellerich
Kun-Hui Lu
Anna Tafuri
Tony Pawson
Jürgen Wienands
Michael Engelke
Facundo D. Batista

The adaptor Nck is known for linking TCR signaling to cytoskeleton regulation. Batista and colleagues show that in B cells, Nck recruits the adaptor BCAP to the BCR to activate the PI(3)K pathway.

Keywords:

Cell biology
Cytoskeleton
PI3K/AKT/mTOR pathway
Pi
breakpoint cluster region
T-cell receptor
Biology
Tyrosine
Phosphorylation
Signal transduction
Phosphatidylinositol 3-Kinases
Proto-Oncogene Proteins c-akt

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